NMN: Revolutionary anti-age supplement or one big scam?

Few supplements have experienced such a huge boom recently as NMN. In just a few months, these three letters have made their way into the consciousness of people who often have nothing to do with fitness or strengthsports, and each time it is presented as a functional anti-aging supplement that has a whole host of other potential benefits for our health. But is this really the case? What do scientific studies say about NMN and who should (not) use it? That's what we'll focus on in this comprehensive article.

What is NMN?

NMN stands for a substance called nicotinamide mononucleotide, which is a substance very similar to vitamin B3. In our body, NMN functions as a precursor to nicotinamide adenine dinucleotide (NAD+), which is found in every cellin every cell of our body and which acts as an indispensable compound for the functioning of a number of enzymes. Although this substance is relatively new in this country, in the United States it is being used across supplements, it has been around for quite a long time and, it should be noted, has been the subject of a number of controversies.

The Food and Drug Administration (FDA) there even officially excluded the substance from the list of legal dietary supplements at the end of 2022. However, this was not because of any significant potential harmfulness, but because NMN is currentlycurrently undergoing clinical trials as a drug and cannot be sold as a dietary supplement due to this conflict.

Where is NMN found?

NMN is a metabolite of vitamin B3 and you should know that it is not a science fiction substance, but it is a lovefound in many common ingredients in our diets. For example, NMN is found in mushrooms, tomatoes, avocados, broccoli and dairy products. However, as is usually the case, the amount present in food is relatively small and if you would like to obtainIf you wanted to get as much NMN from your diet as, for example, supplements, you would have to eat dozens of kilograms. Supplementation is therefore much more effective.

What are the claimed benefits of NMN?

NMN has been referred to from time to time as an absolutely revolutionary anti-ageing supplement. But beyond that, there are a number of other often-discussed benefits that NMN may possess. Let's take a look at what some of the research that has been done talks about.

Increases NAD+ levels

As we mentioned in a previous paragraph of this article, NMN acts as a precursor to NAD+. In doing so, one relatively recent study found that 12-week supplementation with 250 mg of NMN actually resulted in a significant increase in blood NAD+ levels compared to placebo. Opponents might argue that this study was nonetheless funded by the NMN company, and therefore the threee should be pointed out that other studies, such as that by Karol Pencina (2023) or Yi et al. (2023).

Can it affect the performance of

Since NAD+ plays a role in a huge number of processes in our bodies, it can also affect our overall health and performance. For example, the aforementioned research showed that physical performance measured by a six-minute walk test was higher in healthy menmiddle-aged men taking NMN were higher than the same group of participants taking a placebo. At the same time, according to other studies, NMN also seems to have a positive effect on aerobic capacity, which is especially appreciated by runners.

May affect insulin sensitivity

In addition, there are also scientific papers that suggest that increasing NAD+ levels can improve, for example, the body's sensitivity to insulin. However, the research conducted involved women who were obese or overweight, who were also post-menopausal and hadprediabetes, so at this stage it is not yet possible to say whether this effect is replicable in healthy individuals.

It may lengthen telomeres

You can think of telomeres as the end parts of our chromosomes that have the property thatthat they get shorter with age, and this plays a major role in the human ageing process. There has also been one scientific paper published on this subject , which, in both mice and humansstudy participants taking NMNs showed an increase in telomere length in both humans and mice. This research may well support the idea that NMN supplementation may be beneficial against aging. However, it should be noted that further research is needed and at this stagestage, we should not have too high expectations of NMNs.

Does NMN have side effects?

As far as side effects are concerned, for most people taking NMN is safe. Scientific studies conducted in which participants took 250 mg of the substance allhowever, suggest that mild abdominal pain may occur, including abdominal pain, diarrhea or gas. Therefore, it is of course advisable to monitor your body when taking this substance.body reacts and if you notice any problems, it is better to stop taking NMN.

How to dose NMN?

At this stage, it is also very difficult to determine what the ideal dose looks like. Studies often work with an amount of around 250 mg, which can be considered sufficient. However, there are also studies that work with significantly higher doses and come up with, among other thingsthat there is no significant difference between taking 600 mg and 1200 mg in terms of effect. We would therefore recommend sticking to the dosage recommended by the manufacturer on the packaging of the supplement you buy.

Which NMN to choose?

While NMN can only be found sub-counter in the United States, it is manufactured by a number of manufacturers here. We, for example, have already reviewed NMN from Minus Age on our site , which we liked for its no(two doctors are behind the Minus Age brand, and they regularly check the quality of the supplements with the Faculty of Pharmacy at Masaryk University). However, products containing NMN are also produced by BrainMax under the name EnEmEn. This product can be viewed via the link below.

Conclusion.

In conclusion, we would like to think about NMN a little more critically. In fact, to date, a number of different scientific studies have already appeared that point to the possible positive benefits of this substance. And of course we would not dare to contradict their results in any way. However, it is worth reading them in light of the fact that the positive results so far show mainly animal studies and the findings in humans may be somewhat different. For example, the aforementioned study involving women with prediabetes looks very promising, but only until you realise that the authors are the people named as inventors on some of the patents for the use of NMN. Because at this point it is already known that supplements containing NMN are generally speaking usually easily toleratedtolerated, feel free to try any of the above supplements and experience the effect for yourself on your own body. However, we definitely recommend not to have any miraculous expectations from these supplements. We were satisfied with them in our review of Minus Age NMN, however, in the review itself we add that the placebo effect may have played a role as well.